circRNA basic information
circBase ID: hsa_circ_0025039
Name: hsa_circ_FOXM1
Synonym: Circ_0025039
Host Gene: hsa-miR-636
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human NSCLC cell lines (A549, H1299), human bronchial epithelial cell (16HBE), human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-636
Biological function: circ_0025039 depletion repressed NSCLC cell proliferation, migration, invasion, tube-forming capacity, and sphere formation ability, but induced cell apoptosis.
Molecular mechanism: circ_0025039 acted as a sponge for hsa-miR-636, which was found to target CORO1C.
Survival: -
Supported No.:
 4
Description:

Circ_0025039 silencing repressed NSCLC malignant progression by reducing CORO1C expression through miR-636, showing the possibility of circ_0025039 as a therapeutic target for NSCLC.
Other information
Title:

Circ_0025039 acts an oncogenic role in the progression of non-small cell lung cancer through miR-636-dependent regulation of CORO1C.

Journal: Mol Cell Biochem
Published: 2022/1/17
PubMed ID: 35034254