circRNA basic information
circBase ID: hsa_circ_0084904
Name: hsa_circ_KIAA1429
Synonym: circ_0084904
Host Gene: hsa-miR-802
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal ectocervical Ect1/E6E7 cells, HeLa, C-33A, SiHa, ME-180, Caski CC cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-802
Biological function: circ_0084904 impeded cell colony formation, cell cycle progression, migration, invasion, epithelial-mesenchymal transition (EMT), and promoted apoptosis in vitro, as well as diminished tumor growth in vivo.
Molecular mechanism: circ_0084904 targeted hsa-miR-802, and the effects of circ_0084904 silencing were mediated by hsa-miR-802. MAL2 was directly targeted and inhibited by hsa-miR-802, and MAL2 was a functional target of hsa-miR-802.
Survival: -
Supported No.:
 2
Description:

Our study identified circ_0084904 as a novel oncogenic driver in CC depending on the modulation of the miR-802/MAL2 axis, establishing the notion that silencing of circ_0084904 might represent a promising targeted therapy for CC.
Other information
Title:

The novel circ_0084904/miR-802/MAL2 axis promotes the development of cervical cancer.

Journal: Reprod Biol
Published: 2022/1/17
PubMed ID: 35033901