circRNA basic information
circBase ID: hsa_circ_0007290
Name: -
Synonym: circ_0007290
Host Gene: hsa-miR-496
 
 
 
Disease basic information
DO ID:
3526
DO name: cerebral infarction
Disease details: ischemic stroke
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCN-2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PDCD4
Associated microRNA: hsa-miR-496
Biological function: OGD stimulation induced neuronal apoptosis, promoted LDH release, and enhanced inflammation in HCN-2 cells, which all were reversed by the knockdown of circ_0007290.
Molecular mechanism: _irc_0007290 served as a sponge for miR-496 to relieve the repression of miR-496 on the expression of its target PDCD4.
Survival: -
Supported No.:
1
Description:

Knockdown of circ_0007290 alleviated OGD-induced neuronal injury by regulating miR-496/PDCD4 axis, providing a novel insight into the pathology of ischemic stroke.

Other information
Title:

Knockdown of circ_0007290 alleviates oxygen-glucose deprivation-induced neuronal injury by regulating miR-496/PDCD4 axis.

Journal: Metab Brain Dis
Published: 2022/1/16
PubMed ID: 35032277