circRNA basic information
circBase ID: hsa_circ_0001460
Name: hsa_circ_NEIL3
Synonym: circNEIL3
Host Gene: -
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human glioma cell lines (A172, U251), patient-derived GSC cell lines and neural progenitor cells (NPCs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF2BP3
Associated microRNA: -
Biological function: circNEIL3 promotes tumorigenesis and carcinogenic progression of glioma in vitro and in vivo. Moreover, circNEIL3 overexpression glioma cells drives macrophage infiltration into the tumour microenvironment (TME).
Molecular mechanism: circNEIL3 stabilizes IGF2BP3 (insulin-like growth factor 2 mRNA binding protein 3) protein, a known oncogenic protein, by preventing HECTD4-mediated ubiquitination.
Survival: poor
Supported No.:
 1
Description:

This work reveals that circNEIL3 plays a nonnegligible multifaceted role in promoting gliomagenesis, malignant progression and macrophage tumour-promoting phenotypes polarization, highlighting that circNEIL3 is a potential prognostic biomarker and therapeutic target in glioma.
Other information
Title:

EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3.

Journal: Mol Cancer
Published: 2022/1/16
PubMed ID: 35031058