circRNA basic information
circBase ID: hsa_circ_0000658
Name: hsa_circ_MCTP2
Synonym: Circ_0000658
Host Gene: hsa-miR-498
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal bladder epithelial cell line (SV-HUC-1), BCa cell lines (MGH-U3, T24, 5637, SW780)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-498
Biological function: Circ_0000658 elevation or miR-498 knockdown augmented oncogenic phenotypes and EMT of BCa cells, corresponding to a reduction in the expression of beta-catenin and E-cadherin as well as an increase in the expression of N-cadherin, Slug, Snail, ZEB1 and Twist.
Molecular mechanism: circ_0000658 weakened the binding of hsa-miR-498 to the target gene HMGA2 and upregulated the HMGA2 expression.
Survival: poor
Supported No.:
 2
Description:

our study uncovered the tumor-promoting role of circ_0000658 in BCa via the miR-498/HMGA2 axis.
Other information
Title:

Circ_0000658 knockdown inhibits epithelial-mesenchymal transition in bladder cancer via miR-498-induced HMGA2 downregulation.

Journal: J Exp Clin Cancer Res
Published: 2022/1/16
PubMed ID: 35031054