circRNA basic information
circBase ID: hsa_circ_0001658
Name: hsa_circ_ARID1B
Synonym: -
Host Gene: hsa-miR-182
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human gastric epithelial cell line (GES-1), human GC cell lines (AGS, HGC27)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-182
Biological function: GC cell viability and autophagy were inhibited and apoptosis was promoted after circ_0001658 knockdown
Molecular mechanism: Our research suggests that circ_0001658 acts as a competing endogenous RNA to regulate the viability, autophagy, and apoptosis of GC cells via the hsa-miR-182/RAB10 axis.
Survival: -
Supported No.:
 1
Description:

Our research suggests that circ_0001658 acts as a competing endogenous RNA to regulate the viability, autophagy, and apoptosis of GC cells via the miR-182/RAB10 axis. Knockdown of circ_0001658 may be an alternative treatment for GC.
Other information
Title:

Circular RNA hsa_circ_0001658 regulates apoptosis and autophagy in gastric cancer through microRNA-182/Ras-related protein Rab-10 signaling axis.

Journal: Bioengineered
Published: 2022/1/16
PubMed ID: 35030981