circRNA basic information
circBase ID: hsa_circ_0000515
Name: hsa_circ_RPPH1
Synonym: circ_0000515
Host Gene: hsa-miR-542-3p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: BC cell lines (RT4, RT-112, UMUC3, BIU-87), human bladder epithelial cell line (SV-huc-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-542-3p
Biological function: Knocking down circ_0000515 could significantly repress the growth, migration and aggressiveness of BC cells while overexpression of circ_0000515 showed opposite effects.
Molecular mechanism: Circ_0000515 was validated to adsorb hsa-miR-542-3p, and ILK was testified as the downriver target of hsa-miR-542-3p. Circ_0000515 could ascend ILK expression through repressing that of hsa-miR-542-3p.
Survival: -
Supported No.:
 2
Description:

Circ_0000515, as a tumor promoter, strengthens the viability, migration and aggressiveness of BC cells via modulating miR-542-3p/ILK axis.
Other information
Title:

Circular RNA circ_0000515 adsorbs miR-542-3p to accelerate bladder cancer progression via up-regulating ILK expression.

Journal: Aging (Albany NY)
Published: 2022/1/15
PubMed ID: 35029589