circRNA basic information
circBase ID: -
Name: hsa_circ_RELL1
Synonym: circRELL1
Host Gene: hsa-miR-637
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human gastric cancer cell lines (AGS, SGC-7901, MKN45, MGC823), normal cell lines (GES-1, HEK-293)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-637
Biological function: circRELL1 could block cell proliferation, invasion, migration, and anti-apoptosis in patients
Molecular mechanism: Further mechanism investigation demonstrated that circRELL1 could sponge hsa-miR-637 and indirectly unregulated the expression of EPHB3 via modulating autophagy activation in GC.
Survival: poor
Supported No.:
 1
Description:

Taken together, this study elucidates the suppressive roles of circRELL1/miR-637/EPHB3 axis through autophagy activation in GC progression, inspiring for further understanding of the underlying molecular mechanisms of GC and providing a promising novel diagnostic circulating biomarker and therapeutic target in GC.
Other information
Title:

Exosomal circRELL1 serves as a miR-637 sponge to modulate gastric cancer progression via regulating autophagy activation.

Journal: Cell Death Dis
Published: 2022/1/15
PubMed ID: 35027539