circRNA basic information
circBase ID: hsa_circ_0000467
Name: hsa_circ_SKA3
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human HCC cell lines (Hep3B, Huh7, HepG2, SKHep-1, PLC/PRF/5)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TKS5
Associated microRNA: -
Biological function: promotes the proliferation and invasion
Molecular mechanism: -
Survival: -
Supported No.:
 2
Description:

Thus, our results showed that the heterogeneously expressed circRNA circSKA3 is complexed with integrin beta1 and TKS5 to form exosomes. circSKA3 can be transmitted via tumor-derived exosomes to potentiate the invasive potential of breast cancer cells expressing lower levels of circSKA3. Transmission of circSKA3 allows for the maintenance of advantageous invasive sub-clones in breast cancer.
Other information
Title:

Promotion of tumor progression by exosome transmission of circular RNA circSKA3.

Journal: Mol Ther Nucleic Acids
Published: 2022/1/14
PubMed ID: 35024241