circRNA basic information
circBase ID: hsa_circ_0001206
Name: hsa_circ_CRKL
Synonym: Circ_0001206
Host Gene: hsa-miR-665
 
 
 
Disease basic information
DO ID:
 5844
DO name: myocardial infarction
Disease details: myocardial Infarction
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human cardiomyocytes (H9C2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-665
Biological function: Circ_0001206 overexpression promoted cell viability and inhibited cardiomyocyte apoptosis.
Molecular mechanism: circ_0001206 regulated CRKL expression via acting as a competing endogenous RNA (ceRNA) of microRNA-665 (hsa-miR-665).
Survival: better
Supported No.:
 1
Description:

Circ_0001206 regulates miR-665/CRKL axis to alleviate H/R-induced cardiomyocyte injury in MI. Our findings suggest that circ_0001206 might be a potential target for MI treatment.
Other information
Title:

Circ_0001206 regulates miR-665/CRKL axis to alleviate hypoxia/reoxygenation-induced cardiomyocyte injury in myocardial infarction.

Journal: ESC Heart Fail
Published: 2022/1/14
PubMed ID: 35023295