circRNA basic information
circBase ID: -
Name: hsa_circ_CSNK1G1
Synonym: circ-CSNK1G1
Host Gene: hsa-miR-149-5p
 
 
 
Disease basic information
DO ID:
 1781
DO name: thyroid gland cancer
Disease details: thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: thyroid cancer cell lines (IHH_4, HTH83, KTC_1, SW579, TPC_1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-149-5p
Biological function: circ-CSNK1G1 knockdown inhibited proliferation, survival, and invasion in cancer cells, and tumor growth in mouse models.
Molecular mechanism: miR-149-5p was a target of circ-CSNK1G1, and the anti-tumor effects of circ-CSNK1G1 knockdown were abolished by hsa-miR-149-5p downregulation. In addition, hsa-miR-149-5p directly targeted MAPK1, and hsa-miR-149-5p restoration-inhibited cell proliferation and invasion were recovered by MAPK1 overexpression.
Survival: -
Supported No.:
 1
Description:

Circ-CSNK1G1 acted as miR-149-5p to relieve the inhibition of miR-149-5p on MAPK1, thus promoting the malignant development of thyroid cancer.
Other information
Title:

CircRNA casein kinase 1 gamma 1 (circ-CSNK1G1) plays carcinogenic effects in thyroid cancer by acting as miR-149-5p sponge and relieving the suppression of miR-149-5p on mitogen-activated protein kinase 1 (MAPK1).

Journal: J Clin Lab Anal
Published: 2022/1/14
PubMed ID: 35023214