circRNA basic information
circBase ID: hsa_circ_0003221
Name: hsa_circ_PTK2
Synonym: Circ_0003221
Host Gene: hsa-miR-139-3p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: common cervical cancer cell lines (SiHa, CaSki, C33A, HeLa), nan-cancer cervical cell line (Ect1/E6E7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-139-3p
Biological function: Circ_0003221 was highly expressed in cancer tissues and cells, and its downregulation suppressed cancer cell proliferation, migration, invasion, and angiogenesis and also delayed tumor growth in vivo.
Molecular mechanism: Circ_0003221 bound to hsa-miR-139-3p and sequestered hsa-miR-139-3p expression. S100A14 was a target gene of hsa-miR-139-3p. hsa-miR-139-3p upregulation repressed cancer cell malignant phenotypes by depleting S100A14.
Survival: poor
Supported No.:
 2
Description:

circ_0003221 positively regulated S100A14 expression by targeting miR-139-3p. Circ_0003221 downregulation restrains cervical cancer cell growth, metastasis, and angiogenesis by governing the miR-139-3p/S100A14 pathway.
Other information
Title:

Circ_0003221 Downregulation Restrains Cervical Cancer Cell Growth, Metastasis and Angiogenesis by Governing the miR-139-3p/S100A14 Pathway.

Journal: Reprod Sci
Published: 2022/1/14
PubMed ID: 35023052