circRNA basic information
circBase ID: -
Name: hsa_circ_BRAP
Synonym: CircBRAP
Host Gene: hsa-miR-106b
 
 
 
Disease basic information
DO ID:
 10591
DO name: pre-eclampsia
Disease details: Preeclampsia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: TEV-1 trophoblast cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HIF-2A
Associated microRNA: hsa-miR-106b
Biological function: predictive power was strengthened when the plasma sFLT1 and CircBRAP levels were combined with the UtA-PI to predict preeclampsia occurrence.
Molecular mechanism: CircBRAP may regulate miR-106b and the HIF-2A axis to modulate the proliferation, invasion, and apoptosis of TEV-1 trophoblast cells.
Survival: -
Supported No.:
 1
Description:

placenta-derived CircBRAP in plasma may be a novel biomarker for preeclampsia that, together with plasma sFLT1 levels and uterine artery Doppler ultrasound findings, can more effectively predict preeclampsia, and CircBRAP may play a potential role in preeclampsia.
Other information
Title:

A Novel Circular RNA CircBRAP May Be Used as an Early Predictor of Preeclampsia and Its Potential Mechanism.

Journal: Reprod Sci
Published: 2022/1/12
PubMed ID: 35015290