circRNA basic information
circBase ID: -
Name: hsa_circ_ASAP1
Synonym: circ_0008934
Host Gene: hsa-miR-1305
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human hepatic cell line (LO2), HCC cell lines (HepG2, HepG3B, PLC/PRF/5, HuH7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1305
Biological function: knockdown of circ_0008934 inhibited HCC cell proliferation, invasion and migration in vitro and vivo.
Molecular mechanism: circ_0008934 was a sponge of hsa-miR-1305 to facilitate the TMTC3 expression
Survival: poor
Supported No.:
 3
Description:

Overall, these results demonstrate that downregulation of circ_0008934 repress HCC growth and metastasis by upregulating miR-1305 to inhibit TMTC3, suggesting circ_0008934/ miR-1305/ TMTC3 regulatory axis may be a possible novel therapeutic target for HCC.
Other information
Title:

Circular RNA circ_0008934 promotes hepatocellular carcinoma growth and metastasis through modulating miR-1305/TMTC3 axis.

Journal: Hum Cell
Published: 2022/1/12
PubMed ID: 35015267