circRNA basic information
circBase ID: -
Name: hsa_circ_MIIP
Synonym: CircMIIP
Host Gene: hsa-miR-766-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human NSCLC cell lines (NCI-H23, A549), normal human lung epithelial cell line (BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-766-5p
Biological function: circMIIP knockdown restrained the proliferation, migration and invasion and induced the apoptosis of NSCLC cells.
Molecular mechanism: CircMIIP acted as a molecular sponge for hsa-miR-766-5p, and circMIIP silencing-mediated anti-tumor effects were largely overturned by the knockdown of hsa-miR-766-5p in NSCLC cells. hsa-miR-766-5p interacted with the 3 untranslated region (3UTR) of FAM83A, and FAM83A overexpression largely reversed hsa-miR-766-5p accumulation-induced anti-tumor effects in NSCLC cells.
Survival: -
Supported No.:
 1
Description:

CircMIIP promoted cell proliferation, migration and invasion and suppressed cell apoptosis in NSCLC cells through mediating miR-766-5p/FAM83A axis.
Other information
Title:

CircMIIP Contributes to Non-Small Cell Lung Cancer Progression by Binding miR-766-5p to Upregulate FAM83A Expression.

Journal: Lung
Published: 2022/1/12
PubMed ID: 35013754