circRNA basic information
circBase ID: hsa_circ_0004658
Name: hsa_circ_EMILIN2
Synonym: circ_0004658
Host Gene: hsa-miR-499b-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human monocytic cell line (THP-1), HCC cell lines (SMMC-7721and HepG2)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-499b-5p
Biological function: hsa_circ_0004658 inhibits proliferation and promotes apoptosis in HCC cells, whereas hsa_circ_0004658 knockdown stimulated cell proliferation and migration but restrained apoptosis in vitro and promotes tumor growth in vivo.
Molecular mechanism: Mechanistic investigations revealed that hsa_circ_0004658 acts as a ceRNA of hsa-miR-499b-5p, resulting in the de-repression of JAM3. T
Survival: -
Supported No.:
 1
Description:

These results indicate that exosome circRNAs secreted from RBPJ+/+_¦Õ inhibits tumor progression through the hsa_circ_0004658/miR-499b-5p/JAM3 pathway and hsa_circ_0004658 may be a diagnostic biomarker and potential target for HCC therapy.
Other information
Title:

Exosomal hsa_circ_0004658 derived from RBPJ overexpressed-macrophages inhibits hepatocellular carcinoma progression via miR-499b-5p/JAM3.

Journal: Cell Death Dis
Published: 2022/1/12
PubMed ID: 35013102