circRNA basic information
circBase ID: hsa_circ_0020093
Name: hsa_circ_ATRNL1
Synonym: Circ_0020093
Host Gene: hsa-miR-181a-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human chondrocytes C28/I2
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-181a-5p
Biological function: Circ_0020093 overexpression relieved inflammatory responses, cell apoptosis and ECM degradation in IL-1beta-induced C28/I2 cells.
Molecular mechanism: Circ_0020093 directly targeted hsa-miR-181a-5p, and hsa-miR-181a-5p bound to the 3 -untranslated region (3UTR) of ERG to regulate ERG expression. Circ_0020093 overexpression promoted the expression of ERG by sponging hsa-miR-181a-5p.
Survival: -
Supported No.:
 2
Description:

Circ_0020093 overexpression alleviated IL-1beta-induced human chondrocyte inflammatory injury, apoptosis and ECM degradation by targeting miR-181a-5p/ERG pathway.
Other information
Title:

Circ_0020093 Overexpression Alleviates Interleukin-1 Beta-induced Inflammation, Apoptosis and Extracellular Matrix Degradation in Human Chondrocytes by Targeting the miR-181a-5p/ERG Pathway.

Journal: Immunol Invest
Published: 2022/1/12
PubMed ID: 35012421