circRNA basic information
circBase ID: -
Name: hsa_circ_PITX1
Synonym: circ-PITX1
Host Gene: hsa-miR-30e-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NSCLC cells (H1975, A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-30e-5p
Biological function: circ-PITX1 overexpression or miR-30e-5p inhibition markedly facilitated proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), reduced apoptosis, and enhanced ITGA6/PI3K/AKT expression in NSCLC cells
Molecular mechanism: circ-PITX1 acted as a sponge of hsa-miR-30e-5p, which targeted the 3untranslated region (UTR) of ITGA6. Knockdown of circ-PITX1 or overexpressing hsa-miR-30e-5p reduced ITGA6/PI3K/AKT axis.
Survival: poor
Supported No.:
 3
Description:

circ-PITX1 modulates the miR-30e-5p/ITGA6 axis to boost NSCLC progression, hence functioning as an oncogene.
Other information
Title:

The circ-PITX1 promotes non-small cell lung cancer development via the miR-30e-5p/ITGA6 axis.

Journal: Cell Cycle
Published: 2022/1/11
PubMed ID: 35007184