circRNA basic information
circBase ID: hsa_circ_0001495
Name: hsa_circ_CCNB1
Synonym: CircCCNB1
Host Gene: hsa-miR-106b-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-106b-5p
Biological function: circCCNB1 silencing promoted the clone formation ability, the cell cycle G1-S transition, and the growth of xenograft tumors of HCC cells
Molecular mechanism: the mechanism of downstream gene DYNC1I1 and AKT/ERK signaling pathway via the circCCNB1/hsa-miR-106b-5p/GPM6A network in regulating the cell cycle was also explored.
Survival: -
Supported No.:
 1
Description:

We demonstrated that circCCNB1 silencing promoted cell proliferation and metastasis of HCC cells by weakening sponging of oncogenic miR-106b-5p to induce GPM6A underexpression. DYNC1I1 gene expression was up-regulated and further led to activation of the AKT/ERK signaling pathway.
Other information
Title:

CircCCNB1 silencing acting as a miR-106b-5p sponge inhibited GPM6A expression to promote HCC progression by enhancing DYNC1I1 expression and activating the AKT/ERK signaling pathway.

Journal: Int J Biol Sci
Published: 2022/1/11
PubMed ID: 35002514