circRNA basic information
circBase ID: hsa_circ_0003288
Name: hsa_circ_BIRC6
Synonym: circ_0003288
Host Gene: hsa-miR-145
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cell lines (NCI-H460, A549, NCI55 H1650, NCI-H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-145
Biological function: Overexpression of hsa_circ_0003288 dramatically promoted lung cancer cell proliferation, colony formation, inhibited apoptosis, and increased cell migration and invasion in vitro.
Molecular mechanism: hsa_circ_0003288 negatively regulated hsa-miR-145 to exert the oncogenic role in lung cancer.
Survival: -
Supported No.:
 5
Description:

Collectively, these findings identified a novel regulatory role of hsa_circ_0003288/miR-145 axis in the progression of NSCLC.
Other information
Title:

Hsa_circ_0003288 facilitates tumor progression by targeting miR-145 in non-small cell lung cancer cells.

Journal: Cancer Biomark
Published: 2022/1/11
PubMed ID: 35001875