circRNA basic information
circBase ID: hsa_circ_0017639
Name: hsa_circ_SFMBT2
Synonym: Circ_0017639
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cell lines (A549, H1299, H1755, H2170), bronchial epithelial cells (16HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circ_0017639 overexpression was able to promote proliferative, migratory, and invasive properties of NSCLC cells
Molecular mechanism: circ_0017639 knockdown suppressed the cellular development via PI3K/AKT cascade inactivation.
Survival: -
Supported No.:
 4
Description:

We showed that circ_0017639 considerably contributes to the NSCLC development. High circ_0017639 expression was found in NSCLC cells and tissues. It was revealed that an elevated expression of circ_0017639 enhanced the proliferative, migratory, and invasive potential of NSCLC cells through triggering PI3K/AKT signaling cascade, which may provide the experimental evidence for the further targeted intervention therapy of NSCLC.
Other information
Title:

Circ_0017639 facilitates proliferative, migratory, and invasive potential of non-small cell lung cancer (NSCLC) cells via PI3K/AKT signaling pathway.

Journal: Bioengineered
Published: 2022/1/11
PubMed ID: 35000535