circRNA basic information
circBase ID: -
Name: hsa_circ_ABCC1
Synonym: CircABCC1
Host Gene: hsa-miR-591
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human glioma cell lines (A172, U87, U251, T98G), normal human astrocytes (NHA)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-591
Biological function: circABCC1 was upregulated in glioma tissues and cell lines and that the suppression of circABCC1 inhibited the proliferation, migration, invasion, and subcutaneous glioma growth while it promoted apoptosis of glioma cells.
Molecular mechanism: circABCC1 positively regulated HMGA2 via impairing hsa-miR-591 expression.
Survival: -
Supported No.:
 1
Description:

circABCC1 promotes the expression of HMGA2 via sponging of miR-591, thus affecting glioma progression as an important onco-circRNA.
Other information
Title:

CircABCC1 promotes the development of glioma by sponging miR-591 and modulating high-mobility group A2.

Journal: Ann N Y Acad Sci
Published: 2022/1/10
PubMed ID: 35000195