circRNA basic information
circBase ID: -
Name: hsa_circ_MACF1
Synonym: circ_MACF1
Host Gene: hsa-miR-942-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: gefitinib-resistant NSCLC cells (PC9/GR, A549/GR)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-942-5p
Biological function: Everexpression of circ_MACF1 repressed proliferation, migration, invasion, and promoted apoptosis and gefitinib sensitivity of A549/GR and PC9/GR cells in vitro, as well as inhibited tumor growth under gefitinib in vivo.
Molecular mechanism: Circ_MACF1 directly targeted hsa-miR-942-5p, and hsa-miR-942-5p mediated the regulatory effects of circ_MACF1. TGFBR2 was identified as a direct and functional target of hsa-miR-942-5p. Circ_MACF1 modulated TGFBR2 expression through hsa-miR-942-5p.
Survival: -
Supported No.:
 2
Description:

Our findings demonstrated that circ_MACF1 regulated cell functional behaviors and gefitinib sensitivity of A549/GR and PC9/GR cells at least partially by targeting miR-942-5p to induce TGFBR2 expression.
Other information
Title:

A novel circ_MACF1/miR-942-5p/TGFBR2 axis regulates the functional behaviors and drug sensitivity in gefitinib-resistant non-small cell lung cancer cells.

Journal: BMC Pulm Med
Published: 2022/1/9
PubMed ID: 34996416