circRNA basic information
circBase ID: hsa_circ_0044516
Name: -
Synonym: Circ_0044516
Host Gene: hsa-miR-330-5p
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: PCa cell lines (DU145, LNCaP), normal prostatic cell (RWPE-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-330-5p
Biological function: circ_0044516 knockdown suppressed PCa cell proliferation, migration, invasion, and cycle progression
Molecular mechanism: Circ_0044516 acted as a hsa-miR-330-5p sponge to block hsa-miR-330-5p expression, SARM1 was a target of hsa-miR-330-5p
Survival: -
Supported No.:
 2
Description:

circ_0044516 deficiency blocked tumor growth in vivo by regulating the miR-330-5p/SARM1 axis. Circ_0044516 as a miR-330-5p sponge increases SARM1 expression.
Other information
Title:

Circ_0044516 Enriches the Level of SARM1 as a miR-330-5p Sponge to Regulate Cell Malignant Behaviors and Tumorigenesis of Prostate Cancer.

Journal: Biochem Genet
Published: 2022/1/8
PubMed ID: 34993722