circRNA basic information
circBase ID: -
Name: hsa_circ_ANXA2
Synonym: circANXA2
Host Gene: hsa-miR-33a-5p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human lung epithelial cell (BEAS-2B), lung cancer cell lines (A549, NCI-H446, NCI-H460, PC-9, 95-D)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-33a-5p
Biological function: Knocking down of circANXA2 inhibits the proliferation and clonogenesis of the lung cancer cells. Knocking down circANXA2 promotes apoptosis.
Molecular mechanism: circANXA2 further affects downstream PDPK1 expression by regulating hsa-miR-33a-5p and thereby affecting the malignancy of the lung cancer cells.
Survival: -
Supported No.:
 1
Description:

circANXA2 regulates the transcription of the miR-33a-5p downstream target gene PDPK1 and affects the malignant progression of lung cancer.
Other information
Title:

CircRNA ANXA2 Promotes Lung Cancer Proliferation and Metastasis by Upregulating PDPK1 Expression.

Journal: J Oncol
Published: 2022/1/8
PubMed ID: 34992655