circRNA basic information
circBase ID: -
Name: hsa_circ_WAC
Synonym: circWAC
Host Gene: hsa-miR-599
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human BC cell lines (MDA-MB-231, MDA-MB-468, MCF-7, SKBR3), nonmalignant cell line (MCF-10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F3
Associated microRNA: hsa-miR-599
Biological function: circWAC knockdown restrained the proliferation, migration, invasion, and glycolysis and promoted the apoptosis of BC cells.
Molecular mechanism: CircWAC acted as hsa-miR-599 sponge, and hsa-miR-599 interference largely reversed circWAC silencing-induced effects in BC cells. hsa-miR-599 interacted with the 3 untranslated region (3UTR) of E2F3, and hsa-miR-599 overexpression-induced suppressive effect on cellular malignant potential was overturned by the accumulation of E2F3 in BC cells.
Survival: -
Supported No.:
 1
Description:

eIF4A3-induced circWAC promoted the proliferation, migration, invasion, and glycolysis and suppressed the apoptosis of BC cells through mediating miR-599/E2F3 axis, which provided novel potential targets for BC therapy.
Other information
Title:

eIF4A3-induced circWAC promotes breast cancer progression through mediating miR-599/E2F3 axis.

Journal: Kaohsiung J Med Sci
Published: 2022/1/7
PubMed ID: 34989110