circRNA basic information
circBase ID: -
Name: hsa_circ_FBXW8
Synonym: CircFBXW8
Host Gene: hsa-miR-370-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cell lines (A549, PC9), human normal lung epithelial cell-line (BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-370-3p
Biological function: CircFBXW8 depletion repressed NSCLC cell proliferation, migration and invasion, but promoted cell apoptosis.
Molecular mechanism: CircFBXW8 acted as a sponge of hsa-miR-370-3p and regulated NSCLC cell malignancy by binding to hsa-miR-370-3p. Additionally, hsa-miR-370-3p repressed NSCLC cell processes by regulating TRIM44.
Survival: -
Supported No.:
 1
Description:

CircFBXW8 modulated NSCLC progression by increasing TRIM44 expression through sponging miR-370-3p, which provided a new direction for studying the therapy of NSCLC.
Other information
Title:

CircFBXW8 Acts an Oncogenic Role in the Malignant Progression of Non-small Cell Lung Carcinoma by miR-370-3p-Dependent Regulation of TRIM44.

Journal: Biochem Genet
Published: 2022/1/7
PubMed ID: 34988777