circRNA basic information
circBase ID: hsa_circ_0000338
Name: -
Synonym: circ_0000338
Host Gene: hsa-miR-217, hsa-miR-485-3p
 
 
 
Disease basic information
DO ID:
9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SW480, HCT116
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-217, hsa-miR-485-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
2
Description:

The delivery of circ_0000338 via exosomes enhanced 5-FU resistance in CRC through negative regulation of miR-217 and miR-485-3p, indicating a promising diagnostic and therapeutic marker for 5-FU-based chemotherapy in CRC patients.

Other information
Title:

Exosome-Mediated Transfer of circ_0000338 Enhances 5-Fluorouracil Resistance in Colorectal Cancer through Regulating MicroRNA 217 (miR-217) and miR-485-3p.

Journal: Mol Cell Biol
Published: 2021/3/17
PubMed ID: 33722958