circRNA basic information
circBase ID: -
Name: hsa_circ_CCDC85A
Synonym: circCCDC85A
Host Gene: hsa-miR-550a-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: breast cancer cell lines (MDA-MB-231, BT-549, MCF-7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-550a-5p
Biological function: Over-expression of circCCDC85A substantially inhibited the proliferative, migrative, and invasive ability of breast cancer cells, while knocking down of circCCDC85A enhanced the aforementioned properties of breast cancer cells.
Molecular mechanism: enforced expression of circCCDC85A inhibits the oncogenic activity of hsa-miR-550a-5p and increases the expression of MOB1A targeted by hsa-miR-550a-5p.
Survival: -
Supported No.:
 1
Description:

Our findings provide novel evidence that circCCDC85A inhibits the progression of breast cancer by functioning as a molecular sponge of miR-550a-5p to enhance MOB1A expression.
Other information
Title:

Circular RNA circCCDC85A inhibits breast cancer progression via acting as a miR-550a-5p sponge to enhance MOB1A expression.

Journal: Breast Cancer Res
Published: 2022/1/6
PubMed ID: 34983617