circRNA basic information
circBase ID: -
Name: hsa_circ_RTN4
Synonym: CircRTN4
Host Gene: hsa-miR-497-5p
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HEK293 cells, PDAC cell lines (PANC-1, CFPAC-1, SW1990, CAPAN-2, BxPC-3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-497-5p
Biological function: In vitro and in vivo functional studies revealed that circRTN4 promoted PDAC tumor growth and liver metastasis.
Molecular mechanism: circRTN4 interacted with tumor suppressor hsa-miR-497-5p in PDAC cells. CircRTN4 knockdown upregulated hsa-miR-497-5p to inhibit the oncogenic lncRNA HOTTIP expression.
Survival: -
Supported No.:
 1
Description:

The upregulated circRTN4 promotes tumor growth and liver metastasis in PDAC through the novel circRTN4-miR-497-5p-HOTTIP pathway. Also, circRTN4 stabilizes RAB11FIP1 to contribute EMT.
Other information
Title:

CircRTN4 promotes pancreatic cancer progression through a novel CircRNA-miRNA-lncRNA pathway and stabilizing epithelial-mesenchymal transition protein.

Journal: Mol Cancer
Published: 2022/1/6
PubMed ID: 34983537