circRNA basic information
circBase ID: hsa_circ_0001588
Name: hsa_circ_ERBB4
Synonym: Circ_0001588
Host Gene: hsa-miR-1281
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: glioma cell lines (LN-229, U-251MG), normal human astrocytes (NHA), human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1281
Biological function: Circ_0001588 Depletion Inhibited Cell Proliferation, Migration, Invasion, and Tube Formation, but Induced Cell Apoptosis in U-251MG and LN-229 Cells
Molecular mechanism: Circ_0001588 acted as an oncogene in glioma malignant progression by hsa-miR-1281/ERBB4 pathway
Survival: poor
Supported No.:
 1
Description:

Circ_0001588 acted as an oncogene in glioma malignant progression by miR-1281/ERBB4 pathway, suggesting the potential of circ_0001588 as a therapeutic target for glioma.
Other information
Title:

Circ_0001588 Upregulates ERBB4 to Promote Glioma Malignant Progression Through Sponging miR-1281.

Journal: Neurotox Res
Published: 2022/1/5
PubMed ID: 34982356