circRNA basic information
circBase ID: -
Name: hsa_circ_LARP1B
Synonym: circ-LARP1B
Host Gene: hsa-miR-515-5p
 
 
 
Disease basic information
DO ID:
 3151
DO name: skin squamous cell carcinoma
Disease details: cutaneous squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CSCC cell lines (A431, HSC-1), normal human epidermal keratinocytes (NHEK)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-515-5p
Biological function: Circ-LARP1B knockdown suppressed cell viability, colony formation ability, migration, invasion, cell cycle progression, and glycolysis and triggered cell apoptosis in CSCC cells.
Molecular mechanism: hsa-miR-515-5p was a direct target of circ-LARP1B in CSCC cells, and circ-LARP1B silencing-mediated anti-tumor effects were largely counteracted by hsa-miR-515-5p knockdown. hsa-miR-515-5p directly interacted with the 3 untranslated region (3UTR) of TPX2. TPX2 overexpression largely overturned hsa-miR-515-5p-mediated anti-tumor effects in CSCC cells. Circ-LARP1B could up-regulate TPX2 expression by sponging hsa-miR-515-5p in CSCC cells. Circ-LARP1B knockdown suppressed tumor growth_n vivo.
Survival: -
Supported No.:
 5
Description:

circ-LARP1B contributed to CSCC progression by targeting miR-515-5p/TPX2 axis. The circ-LARP1B/miR-515-5p/TPX2 axis might provide novel therapeutic targets for CSCC patients.
Other information
Title:

Circular RNA circ-LARP1B contributes to cutaneous squamous cell carcinoma progression by targeting microRNA-515-5p/TPX2 microtubule nucleation factor axis.

Journal: Bioengineered
Published: 2022/1/5
PubMed ID: 34982022