circRNA basic information
circBase ID: -
Name: hsa_circ_CDYL2
Synonym: circCDYL2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SK-BR-3-R cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: conferred trastuzumab resistance in breast cancer cells in vitro and in vivo.
Molecular mechanism: circCDYL2 stabilized GRB7 by preventing its ubiquitination degradation and enhanced its interaction with FAK, which thus sustained the activities of downstream AKT and ERK1/2.
Survival: -
Supported No.:
 1
Description:

circCDYL2-GRB7-FAK complex plays a critical role in maintaining HER2 signaling, which contributes to trastuzumab resistance and circCDYL2 is a potential biomarker for trastuzumab-resistance in HER2+_C patients.
Other information
Title:

circCDYL2 promotes trastuzumab resistance via sustaining HER2 downstream signaling in breast cancer.

Journal: Mol Cancer
Published: 2022/1/5
PubMed ID: 34980129