circRNA basic information
circBase ID: hsa_circ_0001665
Name: -
Synonym: Circ_0001665
Host Gene: hsa-miR-302a-3p
 
 
 
Disease basic information
DO ID:
 3192
DO name: neurilemmoma
Disease details: vestibular schwannoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Rat pheochromocytoma cell line (PC-12), rat69 schwannoma cell line (RT4-D6P2T), rat Schwann70 cell lines (RSC96, S16Y)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-302a-3p
Biological function: circ_0001665 inhibition was validated to impede the proliferation while inducing the apoptosis of VS cells via functional assays.
Molecular mechanism: circ_0001665 could function as a sponge of microRNA-302a-3p (hsa-miR-302a-3p) to enhance Adam9 expression and to activate EGFR signaling pathway in VS cells.
Survival: -
Supported No.:
 1
Description:

our study identified a novel perspective for exploration into molecular mechanisms in VS.
Other information
Title:

Circ_0001665 Contributes to the Occurrence of Vestibular Schwannoma via Targeting miR-302a-3p/Adam9/EGFR Signaling Pathway.

Journal: Neuroscience
Published: 2022/1/4
PubMed ID: 34979261