circRNA basic information
circBase ID: hsa_circ_0005358
Name: hsa_circ_Gli1
Synonym: circ_0005358
Host Gene: -
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human cervical cancer cell lines (SiHa, C-4I)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Upregulation of hsa_circ_0005358 significantly suppressed the migration and invasion of cervical cancer cells_n vitro, and downregulation of hsa_circ_0005358 had the opposite effect. A mouse model revealed that cervical cancer cells overexpressing hsa_circ_0005358 possessed weaker metastatic potential_n vivo.
Molecular mechanism: RNA-pull-down assay, mass spectrometry, and RNA immunoprecipitation validated the findings that hsa_circ_0005358 functions via its 215-224 sequence, which interacts with polypyrimidine tract-binding protein 1 (PTBP1). RNA-sequencing profiling revealed that CUB-domain-containing protein 1 (CDCP1) is a common target for hsa_circ_0005358 and PTBP1.
Survival: -
Supported No.:
 1
Description:

Our findings reveal the function of hsa_circ_0005358 in tumor metastasis, which may be applied to a potential therapeutic approach for patients with metastatic cervical cancer.
Other information
Title:

hsa_circ_0005358 suppresses cervical cancer metastasis by interacting with PTBP1 protein to destabilize CDCP1 mRNA.

Journal: Mol Ther Nucleic Acids
Published: 2022/1/4
PubMed ID: 34976440