circRNA basic information
circBase ID: hsa_circ_0000620
Name: -
Synonym: Circ_0000620
Host Gene: hsa-miR-671-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HGC27, AGS
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-671-5p
Biological function: Circ_0000620 knockdown reduced cell viability, colony formation, migration, invasion and tube formation capacity of GC cells in vitro.
Molecular mechanism: circ_0000620 directly interacted with hsa-miR-671-5p and circ_0000620 downregulation regulated malignant behaviors of GC cells by upregulating hsa-miR-671-5p. In addition, silencing of circ_0000620 inhibited tumor growth in vivo.
Survival: -
Supported No.:
 1
Description:

Circ_0000620 knockdown inhibited the malignant development of GC partly through modulating the miR-671-5p/MMP2 axis.
Other information
Title:

Circ_0000620 acts as an oncogenic factor in gastric cancer through regulating MMP2 expression via sponging miR-671-5p.

Journal: J Biol Res (Thessalon)
Published: 2022/1/2
PubMed ID: 34972532