circRNA basic information
circBase ID: -
Name: hsa_circ_MKLN1
Synonym: Circ-MKLN1
Host Gene: hsa-miR-377-3p
 
 
 
Disease basic information
DO ID:
 0070353
DO name: cataract
Disease details: posterior capsule opacification
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: SRA01/04 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-377-3p
Biological function: Cell viability, migration, invasion and EMT process
Molecular mechanism: Circ-MKLN1 targeted hsa-miR-377-3p and the regulation of si-circ-MKLN1 for the TGF-beta2-induced influences was related to the upregulation of hsa-miR-377-3p.
Survival: -
Supported No.:
 1
Description:

These results showed that circ-MKLN1 contributed to the progression of PCO_n vitro_y increasing the CTGF expression via sponging miR-377-3p. Circ-MKLN1 might be important for improving the molecular target therapy in PCO.
Other information
Title:

Circ-MKLN1/miR-377-3p/CTGF Axis Regulates the TGF-beta2-induced Posterior Capsular Opacification in SRA01/04 Cells.

Journal: Curr Eye Res
Published: 2021/12/29
PubMed ID: 34961410