circRNA basic information
circBase ID: hsa_circ_0062682
Name: hsa_circ_TPST2
Synonym: circ_0062682
Host Gene: hsa-miR-940
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human CRC cell lines (HCT8, DLD1, HCT116, HT29), normal colorectal epithelial cell lines (NCM460, CCC-HIE-2), HEK-293T (293T) cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-940
Biological function: circ_0062682 knockdown reduced CRC growth both_n vitro_nd_n vivo.
Molecular mechanism: circ_0062682 could sponge hsa-miR-940 and identified D-3-phosphoglycerate dehydrogenase (PHGDH), a key oxidoreductase involved in serine biosynthesis, as a novel target of hsa-miR-940.
Survival: poor
Supported No.:
 1
Description:

these data demonstrate, for the first time, that circ_0062682 promotes serine metabolism and tumor growth in CRC by regulating the miR-940/PHGDH axis, suggesting circ_0062682 as a potential novel therapeutic target for CRC.
Other information
Title:

Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis.

Journal: Front Cell Dev Biol
Published: 2021/12/28
PubMed ID: 34957102