circRNA basic information
circBase ID: hsa_circ_0088364
Name: hsa_circ_MRRF
Synonym: circ_0088364
Host Gene: hsa-miR-1270
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Huh7, HCCLM3 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1270
Biological function: Circ_0088364 was increased in HCC, and blocking circ_0088364 suppressed growth and motility of HCC cells_n vitro
Molecular mechanism: There was a circ_0088364-hsa-miR-1270-COL4A1 ceRNA regulatory axis in HCC
Survival: -
Supported No.:
 2
Description:

In conclusion, circ_0088364 was oncogenic in human HCC, and blocking circ_0088364 could suppress HCC cell growth and motility via regulating miR-1270-COL4A1 interaction. This finding contributed to the understanding of carcinogenic mechanism of circ_0088364 in HCC, and circ_0088364-miR-1270-COL4A1 ceRNA pathway might be a potential therapeutic target to interfere the progression of HCC.
Other information
Title:

Depleting circ_0088364 restrained cell growth and motility of human hepatocellular carcinoma via circ_0088364-miR-1270-COL4A1 ceRNA pathway.

Journal: Cell Cycle
Published: 2021/12/25
PubMed ID: 34951563