circRNA basic information
circBase ID: -
Name: hsa_circ_RFX3
Synonym: CircRFX3
Host Gene: hsa-miR-587
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: U118, U251, U87, A172
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-587
Biological function: The results of a series of overexpression and knockdown assays indicated that circRFX3 could boost the proliferation, invasion, and migration of GBM cells.
Molecular mechanism: circRFX3 could sponge microRNA-587 (hsa-miR-587) to exercise its function as a competing endogenous RNA (ceRNA) in the development of GBM. In addition, PDIA3 was proven to be a downstream target of hsa-miR-587 and to regulate the Wnt/beta-catenin pathway
Survival: -
Supported No.:
 1
Description:

circRFX3 could act as a cancer-promoting circRNA to boost the development of GBM and regulate the miR-587/PDIA3/beta-catenin axis.
Other information
Title:

A Novel Circular RNA CircRFX3 Serves as a Sponge for MicroRNA-587 in Promoting Glioblastoma Progression via Regulating PDIA3.

Journal: Front Cell Dev Biol
Published: 2021/12/25
PubMed ID: 34950658