circRNA basic information
circBase ID: hsa_circ_0001073
Name: hsa_circ_ACVR2A
Synonym: circ_0001073
Host Gene: hsa-miR-582-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: LC cell lines (A549, H460, HCC827, H1299, H1975), human bronchial epithelial cells
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-582-3p
Biological function: circ_0001073_verexpression impeded the multiplication, migration, and invasion and enhanced the apoptosis of NSCLC cells_n vitro.
Molecular mechanism: circ_0001073_irectly bound to_iR-582-3p_nd acted as a miRNA sponge to regulate_GMB_xpression. Besides,_iR-582-3p_verexpression or knockdown of_GMB_emarkably reversed the malignant phenotypes of NSCLC cells induced by the up-regulation ofcirc_0001073_xpression.
Survival: poor
Supported No.:
 1
Description:

Circ_0001073_p-regulates_GMB_xpression through adsorbing_iR-582-3p_o inhibit NSCLC progression, suggesting its potential as a novel therapeutic target in NSCLC.
Other information
Title:

Circular RNA_0001073 (circ_0001073) Suppresses The Progression of Non-Small Cell Lung Cancer via miR-582-3p/RGMB Axis.

Journal: Cell J
Published: 2021/12/24
PubMed ID: 34939762