circRNA basic information
circBase ID: hsa_circ_0094343
Name: hsa_circ_PTEN
Synonym: circPTEN
Host Gene: hsa-miR-4470
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCoEpiC, human CRC cell lines (SW480, HT29, SW620, RKO)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-4470
Biological function: CircPTEN is characterized with high stability due to its circular structure. Upregulation of circPTEN suppressed CRC cell proliferation, migration, and invasion but facilitated apoptosis.
Molecular mechanism: Data from mechanism assays revealed that circPTEN could elevate PTEN expression through sequestering microRNA-4470 (hsa-miR-4470) in CRC cells. Further, circPTEN was validated to inhibit K63-linked ubiquitination of protein kinase B (AKT) and AKT phosphorylation at Thr-308 and Ser-473 by competitively binding with tumor necrosis factor (TNF)-receptor-associated factor 6 (TRAF6). Moreover, the results of rescue assays indicated that the suppressive effect of circPTEN on CRC progression could be totally reversed by overexpression of insulin like growth factor 1 (IGF-1) or partially reversed by knockdown of PTEN.
Survival: -
Supported No.:
 2
Description:

To conclude, circPTEN suppresses CRC progression via regulation of PTEN/AKT pathway.
Other information
Title:

circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway.

Journal: Mol Ther Nucleic Acids
Published: 2021/12/24
PubMed ID: 34938598