circRNA basic information
circBase ID: -
Name: hsa_circ_ARHGAP12
Synonym: CircARHGAP12
Host Gene: hsa-miR-301b-3p
 
 
 
Disease basic information
DO ID:
 9351
DO name: diabetes mellitus
Disease details: diabetic wound
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human MSCs
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-301b-3p
Biological function: MSCs treated with high glucose displayed an evident reduction in circARHGAP12 expression, whereas autophagy mediated by circARHGAP12 suppressed high glucose-triggered apoptosis of MSCs.
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

hese results suggest that circARHGAP12/miR-301b-3p/ATG16L1 and circARHGAP12/miR-301b-3p/ULK2 regulatory networks might be an underlying therapeutic target for MSCs in diabetic wound healing.
Other information
Title:

CircARHGAP12 Triggers Mesenchymal Stromal Cell Autophagy to Facilitate its Effect on Repairing Diabetic Wounds by Sponging miR-301b-3p/ATG16L1 and miR-301b-3p/ULK2.

Journal: J Invest Dermatol
Published: 2021/12/22
PubMed ID: 34933019