circRNA basic information
circBase ID: hsa_circ_0058058
Name: -
Synonym: circ_0058058
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: multiple myeloma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: H929, MM.1S
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-338-3p
Biological function: Circ_0058058 was up-regulated in MM bone marrow aspirates and cells, knockdown of circ_0058058 reduced MM cell proliferation, angiogenesis and metastasis, but induced apoptosis in vitro. In a MM xenograft mouse model, circ_0058058 silencing reduced MM tumor growth and cell proliferation.
Molecular mechanism: Mechanistically, circ_0058058 acted as a sponge for hsa-miR-338-3p to up-regulate ATG14 expression, which was validated to be a target of hsa-miR-338-3p. Rescue assay showed that hsa-miR-338-3p inhibition reversed the antitumor effects of circ_0058058 knockdown on MM cell. Moreover, forced expression of hsa-miR-338-3p suppressed MM cell malignant phenotype, which was abolished by ATG14 up-regulation.
Survival: -
Supported No.:
 2
Description:

Circ_0058058 functions as a sponge for miR-338-3p to elevate ATG14 expression to promote MM cell proliferation, metastasis and angiogenesis, affording a potential therapeutic target for MM prevention.
Other information
Title:

Down-regulation of circ_0058058 suppresses proliferation, angiogenesis and metastasis in multiple myeloma through miR-338-3p/ATG14 pathway.

Journal: J Orthop Surg Res
Published: 2021/12/22
PubMed ID: 34930344