circRNA basic information
circBase ID: hsa_circ_0003074
Name: -
Synonym: circ_0003074
Host Gene: hsa-miR-516b-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MG63, Saos2, human normal osteoblast cell-line (hFOB1.19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-516b-5p
Biological function: Rg3 treatment dramatically decreased circ_0003074 expression in OS cells. Rg3 treatment led to decreased cell proliferation, migration and invasion but increased cell apoptosis, which was attenuated after circ_0003074 overexpression.
Molecular mechanism: Besides, hsa-miR-516b-5p was a target miRNA of circ_0003074 and partially restored circ_0003074-mediated action under Rg3 treatment. Decreasing hsa-miR-516b-5p expression also promoted Rg3-treated OS cell malignancy through KPNA4, which was identified as a target mRNA of hsa-miR-516b-5p. Besides, circ_0003074 induced KPNA4 production owing to the decrease of hsa-miR-516b-5p expression. Furthermore, Rg3 treatment inhibited tumor formation by regulating circ_0003074 in vivo.
Survival: -
Supported No.:
 1
Description:

Rg3 inhibited OS progression through circ_0003074/miR-516b-5p/KPNA4 axis, showing the potential of Rg3 as a therapeutic agent for OS.
Other information
Title:

Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p/KPNA4-dependent manner.

Journal: J Orthop Surg Res
Published: 2021/12/22
PubMed ID: 34930332