circRNA basic information
circBase ID: -
Name: hsa_circ_MET
Synonym: circMET
Host Gene: hsa-miR-410-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human CRC cell lines (LoVo, SW480, RKO, HCT116), 293_ cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-410-3p
Biological function: circMET is substantially upregulated in CRC cell lines and could promote cell proliferation and growth.
Molecular mechanism: By confirming the regulatory relationship between hsa-miR-410-3p and circMET, we propose a new mechanism for the observed sustained activation of MET in CRC.
Survival: poor
Supported No.:
 1
Description:

In conclusion, our work identifies a novel regulatory role of circMET and provides a potential diagnostic biomarker for CRC.
Other information
Title:

Genome-wide circular RNA (circRNA) and mRNA profiling identify a circMET-miR-410-3p regulatory motif for cell growth in colorectal cancer.

Journal: Genomics
Published: 2021/12/21
PubMed ID: 34929287