circRNA basic information
circBase ID: -
Name: hsa_circ_CDK1
Synonym: CircCDK1
Host Gene: hsa-miR-489-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: LCC2, LCC9
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-489-3p
Biological function: The expression of circCDK1 in tumor tissues with Tamoxifen resistance was higher than that in tissues without Tamoxifen resistance. CircCDK1 knockdown strengthened the sensitivity of Tamoxifen in LCC2 and LCC9 cells and reduced Tamoxifen IC50. The downregulation of circCDK1 inhibited LCC2 andLCC9 cell proliferation and promoted cell apoptosis.
Molecular mechanism: CDK1 was the parent gene of circCDK1 and circCDK1 positively regulated CDK1 expression by targeting hsa-miR- 489-3p. CDK1 overexpression reversed the effects of circCDK1 knockdown. hsa-miR-489-3p inhibition also reversed the effects of circCDK1 knockdown. CircCDK1 knockdown was verified to enhance Tamoxifen sensitivity in animal models.
Survival: -
Supported No.:
 1
Description:

CircCDK1 knockdown enhanced the sensitivity of Tamoxifen in breast cancer cells and suppressed cell growth and survival by depleting CDK1 expression via releasing miR- 489-3p.
Other information
Title:

CircCDK1 knockdown reduces CDK1 expression by targeting miR-489-3p to suppress the development of breast cancer and strengthen the sensitivity of Tamoxifen.

Journal: Anticancer Drugs
Published: 2021/12/21
PubMed ID: 34924499