circRNA basic information
circBase ID: hsa_circ_0020303
Name: hsa_circ_CHST15
Synonym: circCHST15
Host Gene: hsa-miR-125a-5p
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: clear cell renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human RCC cell lines (786-O, 769P, ACHN, CAKI-1, A498, OSRC2), human renal proximal tubular epithelial cell line (HK2)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: EIF4EBP1
Associated microRNA: hsa-miR-125a-5p
Biological function: The expression of circCHST15 was higher in ccRCC tissues compared to healthy adjacent kidney tissue and higher in RCC cell lines compared to normal kidney cell lines. The level of circCHST15 was positively correlated with aggressive clinicopathological characteristics, and circCHST15 served as an independent prognostic indicator for overall survival and progression-free survival in patients with ccRCC after surgical resection. Our in vivo and in vitro data indicate that circCHST15 promotes the proliferation, migration, and invasion of ccRCC cells.
Molecular mechanism: Mechanistically, we found that circCHST15 directly interacts with hsa-miR-125a-5p and acts as a microRNA sponge to regulate EIF4EBP1 expression.
Survival: poor
Supported No.:
 1
Description:

We found that sponging of miR-125a-5p to promote EIF4EBP1 expression is the underlying mechanism of hsa_circ_0020303-induced ccRCC progression. This prompts further investigation of circCHST15 as a potential prognostic biomarker and therapeutic target for ccRCC.
Other information
Title:

circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis.

Journal: Mol Cancer
Published: 2021/12/20
PubMed ID: 34922539