circRNA basic information
circBase ID: hsa_circ_0000644
Name: -
Synonym: Circ_0000644
Host Gene: hsa-miR-1205
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human Thyroid epithelial cell line (Nthy-ori3-1), PTC cell lines (IHH4, TPC-1, FTC-133, SW579)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1205
Biological function: In PTC, circ_0000644 was highly expressed, and it was located mainly in the cytoplasm, and it had stable structure. The knockdown of circ_0000644 repressed PTC cell growth, migration, and invasion, and facilitated apoptosis.
Molecular mechanism: Circ_0000644 could directly interact with hsa-miR-1205 to repress the expression of hsa-miR-1205, and it served as a hsa-miR-1205 sponge to modulate E2F3 expression in PTC cells.
Survival: -
Supported No.:
 1
Description:

Circ_0000644 up-regulates E2F3 expression via sponging miR-1205 to promote PTC progression.
Other information
Title:

Circular RNA circ_0000644 promotes papillary thyroid cancer progression via sponging miR-1205 and regulating E2F3 expression.

Journal: Cell Cycle
Published: 2021/12/18
PubMed ID: 34919034