circRNA basic information
circBase ID: -
Name: hsa_circ_FADS2
Synonym: circFADS2
Host Gene: hsa-miR-766-3p
 
 
 
Disease basic information
DO ID:
 3151
DO name: skin squamous cell carcinoma
Disease details: cutaneous squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CSCC cell lines (SCL-1, A-431), human keratinocyte cell line (HaCaT)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-766-3p
Biological function: CircFADS2 overexpression inhibited CSCC cell proliferation, metastasis and glycolysis.
Molecular mechanism: hsa-miR-766-3p was able to directly bind to circFADS2, and circFADS2 played an anti-cancer role in CSCC by downregulating hsa-miR-766-3p. In addition, HOXA9 was a direct target of hsa-miR-766-3p, and hsa-miR-766-3p inhibition suppressed CSCC cell proliferation, metastasis and glycolysis by upregulating HOXA9. Furthermore, circFADS2 acted as a sponge of hsa-miR-766-3p to regulate HOXA9 expression. Besides, circFADS2 suppressed tumor growth in vivo.
Survival: -
Supported No.:
 3
Description:

CircFADS2 suppressed CSCC progression by regulating miR-766-3p/HOXA9 axis, which might provide a promising therapeutic target for CSCC.
Other information
Title:

Circular RNA circFADS2 inhibits the progression of cutaneous squamous cell carcinoma by regulating miR-766-3p/HOXA9 axis.

Journal: Histol Histopathol
Published: 2021/12/17
PubMed ID: 34913472