circRNA basic information
circBase ID: hsa_circ_0003204
Name: hsa_circ_USP36
Synonym: circ_0003204
Host Gene: hsa-miR-188-3p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: cell line
Sample type details: human carotid artery endothelial cells (HCtAECs), THP-1 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-188-3p
Biological function: Circ_0003204 silencing weakened ox-LDL-induced viability inhibition and apoptosis in HCtAECs, and inflammatory response and oxidative stress in THP-1 cells via regulating miR-188-3p.
Molecular mechanism: Circ_0003204 could regulate TRPC6 expression via mediating hsa-miR-188-3p._iR-188-3p overexpression attenuated ox-LDL-induced injury in HCtAECs and THP-1 cells by targeting TRPC6.
Survival: -
Supported No.:
 7
Description:

Circ_0003204 knockdown mitigated ox-LDL-induced injury in HCtAECs and THP-1 cells via regulating the miR-188-3p/TRPC6 axis, indicating that circ_0003204 might play an important role in carotid artery AS.
Other information
Title:

Hsa_circ_0003204 Knockdown Weakens Ox-LDL-Induced Cell Injury by Regulating miR-188-3p/TRPC6 Axis in Human Carotid Artery Endothelial Cells and THP-1 Cells.

Journal: Front Cardiovasc Med
Published: 2021/12/17
PubMed ID: 34912856